http://www.suboxonecenter.org/ < 703-844-0184
The bottom lin eof the research was to show if Dronabinol (used as an appetite stimulant) could suppress opioid withdrawal symptoms – it was unfortunately not effective as expected:
:CB1 receptor activation is a reasonable strategy to pursue for the treatment of opioid withdrawal; however, dronabinol is not a likely candidate given its modest withdrawal suppression effects
of limited duration and previously reported tachycardia during opioid withdrawal.
Dronabinol, a partial CB1 agonist, was evaluated among adults in opioid withdrawal.
Dronabinol 20 and 30 mg doses produced modest evidence of withdrawal suppression.
Higher acute oral doses also produced sinus tachycardia.
Dronabinol is not a likely mono-therapy candidate for opioid withdrawal treatment.
However, CB1 receptor activation may be a reasonable strategy to pursue.